o A., Chen Z., Cao D., Cho Y., Liang B., Schinazi R., Kim B. Biochemical Simulation of Mutation Synthesis and Repair during SARS-CoV-2 RNA Polymerization. Virology (2024). DOI: 10.1016/j.virol.2024.110255 | PMID: 39366027 [Link | PDF]

Gao Y., Raghavan A., Espinosa Garcia S. A., Deng B., Hurtado de Mendoza D., Liang B.* In vitro higher-order oligomeric assembly of the respiratory syncytial virus M2-1 protein with longer RNAs. J Virol 98, e0104624 (2024). DOI: 10.1128/jvi.01046-24 | PMID: 39016557 | PMCID: PMC11334520. [Link | PDF]

Cao D., Gao Y., Chen Z., Gooneratne I., Roesler C., Mera C., D’Cunha P., Antonova A., Katta D., Romanelli S., Wang Q., Rice S., Lemons W., Ramanathan A., Liang B.* Structures of the promoter-bound respiratory syncytial virus polymerase. Nature (2024). DOI: 10.1038/s41586-023-06867-y | PMID: 38123676 | PMCID: 10.1038/s41586-023-06867-y. [Link | PDF | PDBs: 8SNX, 8SNY]

Ahn H., Calderon B. M., Fan X., Gao Y., Horgan N. L., Jiang N., Blohm D. S., Hossain J., Rayyan N. W. K., Osman S. H., Lin X., Currier M., Steel J., Wentworth D. E., Zhou B.*, Liang B.* Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2. J Med Virol 95, e29163 (2023). DOI: 10.1002/jmv.29163 | PMID: 37842796 | PMCID: 10.1002/jmv.29163. [Link | PDF | PDBs: 8T20, 8T21, 8T22, 8T23, 8T25, 8TAZ]

Xu E., Park S., Calderon J., Cao D., Liang B.* In Silico Identification and In Vitro Validation of Repurposed Compounds Targeting the RSV Polymerase. Microorganisms 11, (2023). DOI: 10.3390/microorganisms11061608 | PMID: 37375110 | PMCID: PMC10302583. [Link | PDF]

Gao Y., Raghavan A., Deng B., Lee J., Liang B.* Optimal Conditions for In Vitro Assembly of Respiratory Syncytial Virus Nucleocapsid-like Particles. Viruses 15,  (2023). DOI: 10.3390/v15020344 | PMID: 36851557 | PMCID: PMC9962444. [Link | PDF]

Cao D., Gooneratne I., Mera C., Vy J., Royal M., Huang B., Park Y., Manjunath A., Liang B.* Analysis of Template Variations on RNA Synthesis by Respiratory Syncytial Virus Polymerase. Viruses 15, (2022). DOI: 10.3390/v15010047 | PMID: 36680087 | PMCID: PMC9863079. [Link | PDF]

Ocampo-Chih C., Dennis H., Lall N., Pham N., Liang B., Verma S., Neira Fresneda J. PEBAT, an Intriguing Neurodegenerative Tubulinopathy Caused by a Novel Homozygous Variant in TBCD: A Case Series and Literature Review. Pediatr Neurol 139, 59-64 (2022). DOI: 10.1016/j.pediatrneurol.2022.11.006 | PMID: 36527993 | PMCID: 10.1016/j.pediatrneurol.2022.11.006. [Link | PDF]

Roe M. K., Perez M. A., Hsiao H. M., Lapp S. A., Sun H. Y., Jadhao S., Young A. R., Batista Y. S., Reed R. C., Taz A., Piantadosi A., Chen X., Liang B., Koval M., Snider T. A., Moore M. L., Anderson E. J., Anderson L. J., Stobart C. C., Rostad C. A. An RSV Live-Attenuated Vaccine Candidate Lacking G Protein Mucin Domains Is Attenuated, Immunogenic, and Effective in Preventing RSV in BALB/c Mice. J Infect Dis 227, 50-60 (2022). DOI: 10.1093/infdis/jiac382 | PMID: 36281651 | PMCID: PMC9796166. [Link | PDF]

Wu W., Kim J. S., Bailey A. O., Russell W. K., Richards S. J., Chen T., Chen T., Chen Z., Liang B., Yamauchi M., Guo H. Comparative genomic and biochemical analyses identify a collagen galactosylhydroxylysyl glucosyltransferase from Acanthamoeba polyphaga mimivirus. Sci Rep 12, 16806 (2022). DOI: 10.1038/s41598-022-21197-1 | PMID: 36207453 | PMCID: PMC9546862. [Link | PDF]

Gao Y., Ogilvie C., Raghavan A., Von Hoffmann C., Liang B.* Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus. J Vis Exp, (2021). DOI: 10.3791/62010 | PMID: 34398139 | PMCID: 10.3791/62010. [Link | PDF]

Yang X., Fan D., Troha A. H., Ahn H. M., Qian K., Liang B., Du Y., Fu H., Ivanov A. A. Discovery of the first chemical tools to regulate MKK3-mediated MYC activation in cancer. Bioorg Med Chem 45, 116324 (2021). DOI: 10.1016/j.bmc.2021.116324 | PMID: 34333394 | PMCID: PMC8456368. [Link | PDF]

Cao D., Gao Y., Liang B.* Structural Insights into the Respiratory Syncytial Virus RNA Synthesis Complexes. Viruses 13, (2021). DOI: 10.3390/v13050834 | PMID: 34063087 | PMCID: PMC8147935. [Link | PDF]

Liu H., Zhang Q., Wei P., Chen Z., Aviszus K., Yang J., Downing W., Jiang C., Liang B., Reynoso L., Downey G. P., Frankel S. K., Kappler J., Marrack P., Zhang G. The basis of a more contagious 501Y.V1 variant of SARS-CoV-2. Cell Res, (2021). DOI: 10.1038/s41422-021-00496-8 | PMID: 33893398 | PMCID: PMC8063779. [Link | PDF]

Zandi K., Musall K., Oo A., Cao D., Liang B., Hassandarvish P., Lan S., Slack R. L., Kirby K. A., Bassit L., Amblard F., Kim B., AbuBakar S., Sarafianos S. G., Schinazi R. F. Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase. Microorganisms 9, (2021). DOI: 10.3390/microorganisms9050893 | PMID: 33921971 | PMCID: 10.3390/microorganisms9050893. [Link | PDF]

Gao Y., Cao D., Pawnikar S., Akhter S., Miao Y., Liang B.* Efficient purification and assembly of ribonucleoprotein complex for interaction analysis by MST assay coupled with GaMD simulations. STAR Protoc 2, 100315 (2021). DOI: 10.1016/j.xpro.2021.100315 | PMID: 33659898 | PMCID: PMC7890042. [Link | PDF]

Cao D., Liang B.* Cryo-Electron Microscopy Structures of the Pneumoviridae Polymerases. Viral Immunol 34, 18-26 (2021). DOI: 10.1089/vim.2020.0018 | PMID: 32429800 | PMCID: 10.1089/vim.2020.0018. [Link | PDF]

Zandi K., Amblard F., Musall K., Downs-Bowen J., Kleinbard R., Oo A., Cao D., Liang B., Russell O. O., McBrayer T., Bassit L., Kim B., Schinazi R. F. Repurposing Nucleoside Analogs for Human Coronaviruses. Antimicrob Agents Chemother, (2020) | 10.1128/AAC.01652-20. [Link | PDF]

Cao D., Gao Y., Roesler C., Rice S., D’Cunha P., Zhuang L., Slack J., Antonova A., Romanelli S., Liang B.* In vitroprimer-based RNA elongation and promoter fine mapping of the respiratory syncytial virus.  J Virol (2020). DOI: 10.1128/JVI.01897-20 | PMID: 33028717. [Link | PDF]

Liang B.* Structures of the Mononegavirales Polymerases.  J Virol  94,  (2020). DOI: 10.1128/JVI.00175-20 | PMID: 32847861 | PMCID: PMC7592205. [Link | PDF]

Gao Y., Cao D., Pawnikar S., John K.P., Ahn H.M., Hill S., Ha, J.M., Parikh P., Ogilvie C., Swain A., Yang A., Bell A., Salazar, A., Miao Y.*, Liang, B.* Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with a Short Positive-Sense Gene-End RNA. Structure 28, 979-990 e974 (2020). DOI: 10.1016/j.str.2020.07.001 | PMID: 32697936 | PMCID: PMC7484405. PDF | PDB: 6PZQ]

Cao D., Gao Y., Roesler C., Rice S., D’Cunha P., Zhuang L., Slack J., Domke M., Antonova A., Romanelli S., Keating S., Forero G., Juneja P., Liang B.* Cryo-EM structure of the respiratory syncytial virus RNA polymerase. Nat Commun 11, 368 (2020). DOI: 10.1038/s41467-019-14246-3 | PMID: 31953395 | PMCID: PMC6969064. [Link | PDF | PDB: 6UEN]

Gao Y., Cao D., Ahn H. M., Swain A., Hill S., Ogilvie C., Kurien M., Rahmatullah T., Liang B.* In vitro trackable assembly of RNA-specific nucleocapsids of the respiratory syncytial virus. J Biol Chem 295, 883-895 (2020). DOI: 10.1074/jbc.RA119.011602 | PMID: 31822560 | PMCID: PMC6970927. [Link | PDF]

Jenni S., Bloyet L. M., Diaz-Avalos R., Liang B., Whelan S. P. J., Grigorieff N., Harrison S. C. Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor. Cell Rep 30, 53-60 e55 (2020). DOI: 10.1016/j.celrep.2019.12.024 | PMID: 31914397 | PMCID: PMC7049099. [Link | PDF | PDB: 6U1X]

Trost J. F., Wang W., Liang B., Galloway S. E., Agbogu E., Byrd-Leotis L., Steinhauer D. A. A conserved histidine in Group-1 influenza subtype hemagglutinin proteins is essential for membrane fusion activity. Virology 536, 78-90 (2019). DOI: 10.1016/j.virol.2019.08.005 | PMID: 31401467 | PMCID: PMC6733629. [Link | PDF]

Duan J., Li J., Chen G. L., Ge Y., Liu J., Xie K., Peng X., Zhou W., Zhong J., Zhang Y., Xu J., Xue C., Liang B., Zhu L., Liu W., Zhang C., Tian X. L., Wang J., Clapham D. E., Zeng B., Li Z., Zhang J. Cryo-EM structure of TRPC5 at 2.8-A resolution reveals unique and conserved structural elements essential for channel function. Sci Adv 5, eaaw7935 (2019). DOI: 10.1126/sciadv.aaw7935 | PMID: 31355338 | PMCID: PMC6656536. [Link | PDF |PDB: 6AEI]

Galloway S. E., Liang B., Steinhauer D. A. in  Activation of Viruses by Host Proteases, Böttcher-Friebertshäuser E., Garten W., Klenk H. D., Eds. (Springer International Publishing, Cham, 2018),  chap. Chapter 1, pp. 3-26. DOI: 10.1007/978-3-319-75474-1_1 | ISBN: 978-3-319-75473-4. [Link | PDF]

Morin B., Liang B., Gardner E., Ross R. A., Whelan S. P. J. An In Vitro RNA Synthesis Assay for Rabies Virus Defines Ribonucleoprotein Interactions Critical for Polymerase Activity. J Virol  91,  (2017). DOI: 10.1128/JVI.01508-16 | PMID: 27795419 | PMCID: PMC5165209. [Link | PDF]

Kahle K. T., Flores B., Bharucha-Goebel D., Zhang J., Donkervoort S., Hegde M., Hussain G., Duran D., Liang B., Sun D., Bonnemann C. G., Delpire E. Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter. Science signaling 9, ra77 (2016). DOI: 10.1126/scisignal.aae0546 | PMID: 27485015 | PMCID: PMC5506493. [Link | PDF]

Merner N. D., Chandler M. R., Bourassa C., Liang B., Khanna A. R., Dion P., Rouleau G. A., Kahle K. T. Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia. Front Cell Neurosci 9, 386 (2015). DOI: 10.3389/fncel.2015.00386 | PMID: 26528127 | PMCID: PMC4600830. [Link | PDF]

Liang B., Li Z., Jenni S., Rahmeh A. A., Morin B. M., Grant T., Grigorieff N., Harrison S. C., Whelan S. P. J. Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy. Cell 162, 314-327 (2015). DOI: 10.1016/j.cell.2015.06.018 | PMID: 26144317 | PMCID: PMC4557768. [Link | PDF | PDB: 5A22]

Kahle K. T., Merner N. D., Friedel P., Silayeva L., Liang B., Khanna A., Shang Y., Lachance-Touchette P., Bourassa C., Levert A., Dion P. A., Walcott B., Spiegelman D., Dionne-Laporte A., Hodgkinson A., Awadalla P., Nikbakht H., Majewski J., Cossette P., Deeb T. Z., Moss S. J., Medina I., Rouleau G. A. Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy. EMBO reports 15, 766-774 (2014). DOI: 10.15252/embr.201438840 | PMID: 24928908 | PMCID: PMC4196980. [Link | PDF]

Kahle K. T., Deeb T. Z., Puskarjov M., Silayeva L., Liang B., Kaila K., Moss S. J. Modulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2. Trends in neurosciences 36, 726-737 (2013). DOI: 10.1016/j.tins.2013.08.006 | PMID: 24139641 | PMCID: PMC4381966. [Link | PDF]

Rahmeh A. A., Morin B., Schenk A. D., Liang B., Heinrich B. S., Brusic V., Walz T., Whelan S. P. Critical phosphoprotein elements that regulate polymerase architecture and function in vesicular stomatitis virus. Proc Natl Acad Sci U S A 109, 14628-14633 (2012). DOI: 10.1073/pnas.1209147109 | PMID: 22908284 | PMCID: PMC3437890.  [Link | PDF]

Liang B., Li H. Structures of ribonucleoprotein particle modification enzymes. Q Rev Biophys  44, 95-122 (2011). DOI: 10.1017/S0033583510000235 | PMID: 21108865 | PMCID: PMC5193010. [Link | PDF]

Zhou J., Liang B., Li H. Structural and functional evidence of high specificity of Cbf5 for ACA trinucleotide. RNA  17, 244-250 (2011). DOI: 10.1261/rna.2415811 | PMID: 21149572 | PMCID: PMC3022274. [Link | PDF | PDB: 3MQK]

Rahmeh A. A., Schenk A. D., Danek E. I., Kranzusch P. J., Liang B., Walz T., Whelan S. P. Molecular architecture of the vesicular stomatitis virus RNA polymerase. Proc Natl Acad Sci U S A 107, 20075-20080 (2010). DOI: 10.1073/pnas.1013559107 | PMID: 21041632 | PMCID: PMC2993402. [Link | PDF]

Zhou J., Lv C., Liang B., Chen M., Yang W., Li H. Glycosidic bond conformation preference plays a pivotal role in catalysis of RNA pseudouridylation: a combined simulation and structural study. J Mol Biol 401, 690-695 (2010). DOI: 10.1016/j.jmb.2010.06.061 | PMID: 20615421 | PMCID: PMC2938745. [Link | PDF | PDB: 3LWO 3LWP]

Zhou J., Liang B., Li H. Functional and structural impact of target uridine substitutions on the H/ACA ribonucleoprotein particle pseudouridine synthase. Biochemistry  49, 6276-6281 (2010). DOI: 10.1021/bi1006699 | PMID: 20575532 | PMCID: PMC2928259. [Link| PDF | PDBs: 3LWQ 3LWR 3LWV]

Liang B., Zhou J., Kahen E., Terns R. M., Terns M. P., Li H. Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA. Nat Struct Mol Biol 16, 740-746 (2009). DOI: 10.1038/nsmb.1624 | PMID: 19478803 | PMCID: PMC5706466. [Link | PDF | PDBs: 3HJW 3HJY]

Liang B., Kahen E. J., Calvin K., Zhou J., Blanco M., Li H. Long-distance placement of substrate RNA by H/ACA proteins. RNA 14, 2086-2094 (2008). DOI: 10.1261/rna.1109808 | PMID: 2008.10_rna_long-distance-placement-of-substrate-rna-by-haca-proteins | PMCID: PMC2553744. [Link | PDF]

Liang B., Xue S., Terns R. M., Terns M. P., Li H. Substrate RNA positioning in the archaeal H/ACA ribonucleoprotein complex. Nat Struct Mol Biol 14, 1189-1195 (2007). DOI: 10.1038/nsmb1336 | PMID: 18059286. [Link| PDF | PDB: 2RFK]

Rashid R., Liang B., Baker D. L., Youssef O. A., He Y., Phipps K., Terns R. M., Terns M. P., Li H. Crystal structure of a Cbf5-Nop10-Gar1 complex and implications in RNA-guided pseudouridylation and dyskeratosis congenita. Mol Cell 21, 249-260 (2006). DOI: 10.1016/j.molcel.2005.11.017 | PMID: 16427014. [Link | PDF | PDB: 2EY4]